Endocrine Abstracts

Objective: The aim of the present study was to determine the plasma osteoprotegerin (OPG) levels in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during the last trimester of pregnancy, and to investigate the relationship between OPG and some related factors.Method: In this study, 65 women with GDM and 65 women with NGT were enrolled. Plasma concentration of OPG was measured by enzyme linked immunosorbent assay (ELISA)...

We have revisited the actions of hormones from the anterior pituitary, notably TSH, on bone and bone cells. Traditionally, the bone loss in hyperthyroidism has been attributed solely to elevated circulating levels of thyroid hormones. The role of TSH, which is reduced in all forms of hyperthyroidism, as well as during thyroxine suppressive therapy for thyroid cancer, has never been investigated. We found that haploinsufficiency of the TSH receptor in mice led to bone loss with...

The chicken gonadotropin-releasing hormone receptor (cGnRH-R) is notable for having a cytoplasmic carboxyl-terminal tail, which is not present in the mammalian GnRH-Rs. We have previously shown that the cGnRH-R undergoes rapid agonist-induced internalization, and requires the carboxyl-terminal tail for this process. To investigate the role of the carboxyl-terminal tail of the cGnRH-R in relation to its rapid internalization, and to identify the key residues involved, a series ...